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In Vivo Pharmacology Preclinical Discovery

TCG Lifesciences’ in vivo service provides validated platforms for regular screening as well as in-depth studies in the therapeutic areas of pain (with special focus on neuropathic pain), inflammation and CNS with a proven track record of supporting successful collaborations globally for the past 12 years. The development of platforms for oncology and anti-bacterial screens are in progress. The in vivo team, comprising experts in pharmacology and veterinary sciences, provide complete support from study design to final data analysis and reporting. The team also offers the flexibility of using available platforms for developing customized models efficiently to support the preclinical discovery program. The teams of in vivo scientists work in concert with the in vitro and bioanalytical teams to support more complex study designs like PK/PD correlation including biomarker analysis and to maximize the value of obtained research data.

The TCGLS animal house is equipped with state-of-the-art rodent holding and breeding facility governed by the Institutional Animal Ethics Committee (IAEC), a blanket import license is also in place for procurement of rodent strains from international sources as per project needs. The present facility has been further expanded for capacity enhancement and for AAALAC accreditation.

Efficacy Model Portfolio

Neuropathic pain

  • Spinal Nerve Ligation (Chung’s model)
  • Spared Nerve Injury (Woolf’s model)
  • Chronic Constriction Injury (Bennett’s model)
  • Partial Sciatic Nerve Ligation (Selzter’s model)
  • Tibial Nerve Transection
  • Diabetic neuropathy
  • Chemotherapy-induced neuropathy

Inflammatory pain

  • Ultraviolet Radiation-induced Hyperalgesia
  • Freund’s Adjuvant induced Hyperalgesia
  • Formalin induced Pain
  • Carrageenan induced Hyperalgesia
  • MIA/MMT-induced OA
  • Post Operative Pain (Pain, Brennan’s Model)

Inflammation Acute inflammation

  • Carrageenan induced Paw Edema
  • Carrageenan induced Air Pouch Inflammation
  • LPS induced Endotoxemia
  • LPS induced Lung Inflammation
  • Delayed Type Hypersensitivity

CNS

  • Contextual Fear Conditioning (CFC) test
  • Novel Object Recognition Test (NORT)
  • Forced Swim Test
  • Synaptic Plasticity changes(Field Potential recording in Hippocampal slices)
  • Novelty Suppressed Feeding Test
  • Marble Buying Test

Mechanical & Thermal Nociception

  • Rat Pinch Model
  • Tail Flick

Visceral pain

  • Acetic Acid induced Writhing

Chronic inflammation

  • Collagen induced Arthritis
  • DSS induced Colitis
  • BDL induced Liver Fibrosis
  • BDL induced Liver Cirrhosis
  • CCl4 induced Liver Fibrosis

Oncology

  • Platform development under progress for CDx and PDx models

Early Tox

  • Platform development under progress for LD-50, MTD, DRF Studies

Other Models

  • Streptozotocin-induced T1 Diabetes
  • Locomotor Activity test
  • Motor Liability test in rat with Rotarod

List of state of the art equipment>>

Instruments-–-In-Vivo