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In Vivo Pharmacology Preclinical Discovery

TCG Lifesciences In Vivo service provides validated platforms for in-depth studies in the therapeutic areas of Pain (special focus on Neuropathic pain), Inflammation and CNS.The development of platforms for oncology and anti-bacterial screens are under progress. Our talented team comprising experts in pharmacology and vet services, provide complete support from study designing to final data analysis and reporting.The team also offers the flexibility of using available platforms for developing customized models efficiently to enable your preclinical discovery program. Our team of In Vivo scientists work in concert with our In Vitro and Bioanalytical teams to support more complex study designs like PK/PD correlation including biomarker analysis and maximize the value of obtained research data.

The animal house of TCG Lifesciences is equipped with a state of art holding facility as well as in house breeding capabilities for reliable supply of rodent strains commonly required to support discovery research. TCG Lifesciences also has the blanket import license in place for procuring rodent strains from foreign labs as per project needs.The facility strictly adheres to the ethical guidelines of the Government of India and is under supervision of a fully compliant Institutional Animal Ethics Committee (IAEC).The present facility is under expansion for capacity enhancement as well as fulfillment of criteria for AAALAC accreditation.

Models currently available for employment in projects:

Pain

Neuropathic pain

  • Spinal Nerve Ligation (Chung’s model)
  • Spared Nerve Injury (Woolf’s model)
  • Chronic Constriction Injury (Bennett’s model)
  • Partial Sciatic Nerve Ligation (Selzter’s model)
  • Tibial Nerve Transection
  • Diabetic neuropathy

Inflammatory pain

  • Ultraviolet Radiation induced Hyperalgesia
  • Freund’s Adjuvant induced Hyperalgesia
  • Formalin induced Pain
  • Carrageenan induced Hyperalgesia
  • MIA/MMT-induced OA
  • Post Operative Pain (POP, Brennan’s Model)

Mechanical & Thermal Nociception

  • Rat Pinch Model
  • Tail Flick

Visceral pain

  • Acetic Acid induced Writhing

Inflammation

Acute inflammation

  • Carrageenan induced Paw Edema
  • Carrageenan induced Air Pouch Inflammation
  • LPS induced Endotoxemia
  • LPS induced Lung Inflammation
  • Delayed Type Hypersensitivity

Chronic inflammation

  • Collagen induced Arthritis
  • DSS induced Colitis
  • BDL induced Liver Fibrosis
  • BDL induced Liver Cirrhosis
  • CCl4  induced Liver Fibrosis

CNS

  • Contextual Fear Conditioning (CFC) test 
  • Novel Object Recognition Test (NORT) 
  • Forced Swim Test for Depression
  • Synaptic Plasticity changes (Field Potential recording in Hippocampal slices)
  • Novelty Suppressed Feeding Test
  • Marble Buying Test

Oncology

  • Platform development under progress for CDx and PDx models

 
Early Tox

  • Platform development under progress for LD-50, MTD, DRF Studies

 
Other Models

  • Streptozotocin induced T1 Diabetes
  • Locomotor Activity test
  • Motor Liability test in rat with Rotarod

List of state of the art equipment>>

Instruments-–-In-Vivo