Palladium catalyzed 8-aminoimidazo[1,2-a]pyridine (AIP) directed selective β-C(sp2)–H arylation

DOI: https://doi.org/10.1039/D0OB02134B

Palladium catalyzed arylation of the inert β-C(sp2)–H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of β-site selectivity and tolerates a broad spectrum of functional groups.

Authors: Biswajit Mondal (TCGLS Member), Prasanjit Ghosh, Mrinalkanti Kundu* (TCGLS Member), Tapas Kumar Das (TCGLS Member), Sajal Das*