Chandan K. Mahato (TCGLS Member), Sayan Mukherjee, Mrinalkanti Kundu (TCGLS Member), and Animesh Pramanik
The Journal of Organic Chemistry 2019 84 (2), 1053-1063
Pyrrolidine-oxadiazolone based organocatalysts are envisaged, synthesized, and utilized for asymmetric Michael reactions. Results of the investigations suggest that some of the catalysts are indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to 99%) in high chemical yields (up to 97%) often in short reaction time. As an extension, one enantiopure Michael adduct has been utilized to synthesize optically active octahydroindole.