Published in: Journal, Volume : 44, Issue : 27, Pages : 5121-5124
Author : Portlock, David E.; Naskar, Dinabandhu; West, Laura; Ostaszewski, Ryszard; Chen, Jack J.
Abstract : Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for high throughput biol. screening.