Solid-phase synthesis of five-dimensional libraries via a tandem Petasis-Ugi multi-component condensation reaction

Published in: Journal, Volume : 44, Issue : 27, Pages : 5121-5124

DOI : 10.1016/s0040-4039(03)01119-5

Author : Portlock, David E.; Naskar, Dinabandhu; West, Laura; Ostaszewski, Ryszard; Chen, Jack J.

Abstract : Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for high throughput biol. screening.